Standing at a crossroads, ready to embark on a journey to leave cannabis with Cannaleave by Numi Naturals.

Examining the Science: Natural Compounds and Cannabis Withdrawal in 2025

Cannabis withdrawal syndrome (CWS) is a clinically significant condition that affects almost half of all regular cannabis users attempting to quit.

According to a comprehensive systematic review published in the Journal of Clinical Medicine (2017) and indexed in PubMed Central (PMC5414724), approximately 47% of regular cannabis users experience withdrawal symptoms when attempting to quit.

The study analyzed data from multiple clinical trials involving cannabis cessation, link.

CANNALEAVE Sleep+Recover™ - Phase 1 Natural Sleep Aid | Cannabis Cessation Support* - Numi Naturals

CANNALEAVE Sleep+Recover - Restorative Sleep* Relaxed Mood* 60 capsules - Numi Naturals

CANNALEAVE Sleep+Recover™ - Phase 1 Natural Sleep Aid | Cannabis Cessation Support*

CANNALEAVE Sleep+Recover™ is the first line of defense in your cannabis-free journey. Developed by a NASM-Certified Nutrition + Wellness Coach, this Phase 1 formula addresses the #1 challenge during early cannabis cessation: sleepless nights, night sweats, and withdrawal-induced insomnia.*

Part of CANNALEAVE's Science-Backed 3-Phase Recovery System.
Unlike generic sleep aids, Sleep+Recover™ is precision-formulated specifically for cannabis withdrawal. Our proprietary 3-phase approach targets the distinct neurochemical shifts that occur during each stage of recovery.*

*What CANNALEAVE™ Sleep+Recover Supports:

Deep, Restorative Sleep - Promotes natural sleep cycles disrupted by cannabis cessation*

Calms Withdrawal Cravings - Soothes nighttime urges during the critical first 7-14 days*

Accelerates Recovery - Supports your brain's natural healing through quality sleep*

Restores Neurochemical Balance - Helps reset serotonin and melatonin production after cannabis use*

Our Quit Weed Specific Sleep Formula harnesses 18 carefully curated botanicals, minerals, and nootropics, Sleep+Recover™ works synergistically to support the unique challenges of Phase 1 withdrawal:

Comprehensive Botanical Blend - Time-tested herbs chosen specifically for their calming, sleep-promoting, and craving-reducing properties*

Essential Mineral Complex - Replenishes nutrients commonly depleted during cannabis use*

Targeted Nootropic Support - Supports healthy neurotransmitter function during recovery*

Why Cannabis Withdrawal Disrupts Sleep: Regular cannabis use suppresses REM sleep and natural melatonin production. When you stop, your brain needs time to relearn natural sleep. CANNALEAVE™ Sleep+Recover provides comprehensive nutritional support during this critical 1-2 week window.*

Perfect For:

First 7-14 days of cannabis cessation when insomnia peaks

T-break (tolerance break) sleep restoration

Anyone experiencing post-cannabis sleep disturbances

Individuals wanting natural alternatives to prescription sleep aids

The CANNALEAVE™ Difference - Triple-Certified Quality:
✅ GMP-Certified Manufacturing - Pharmaceutical-grade production standards
✅ FDA-Registered Facility - Produced in regulated U.S. facilities
✅ 3rd-Party Lab Tested - Every batch verified for purity and potency
✅ NASM-Certified Founder - Created by credentialed nutrition professionals
✅ Zero Cannabis/CBD - No THC, CBD, or cannabis-derived compounds

Recommended Use: Take 2 capsules 20-30 minutes before bedtime with 8 oz of water. For best results, use consistently during Phase 1 (first 2-3 weeks), then transition to Phase 2 (Neurofix+Chill™) as sleep normalizes.

Continue Your Journey: Follow our proven 3-Phase Recovery Protocol → Phase 1: Sleep+Recover™ → Phase 2: Neurofix+Chill™ → Phase 3: Calm+Clear™

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before use if pregnant, nursing, or taking medications.

Developed by a NASM-CNC, NASM-CWC - 30+ years wellness research | Certified Nutrition Wellness Coach

The Science Behind Cannabis Withdrawal

Saffron360™ - Saffron Supplement for Mood Support - 88.5mg Pure Saffron Extract with Lab Verified Quality - Supports Dopamine + Serotonin Naturally - Numi Naturals

Saffron360™ - Saffron Supplement for Mood Support - 88.5mg Pure Extract with Lab Verified Quality

$39.97

Premium saffron extract to support boosted mood and lower stress* - with 3x more than the clinically-researched dose and just 3 clean ingredients.

The Only Saffron Supplement With Scannable Proof!

Recent independent testing revealed most saffron supplements contain no saffron compounds. In an industry plagued by inconsistency and unverifiable claims, Saffron360™ delivers revolutionary transparency through scannable QR code technology.

Every bottle connects you directly to third-party lab results from ISO 17025 accredited laboratories. View identity confirmation proving genuine saffron presence, purity verification, and pharmaceutical-grade safety testing. You're not trusting our claims - you're verifying them yourself.

Clinically-Informed Potency That Works

Each capsule delivers 88.5mg of full-spectrum Crocus sativus L. (saffron) extract - three times the dose used in the landmark 2025 clinical study. This concentrated potency naturally contains saffron's trio of bioactive compounds: crocins, picrocrocin, and safranal - shown in research to support optimal dopamine and serotonin balance.*

One capsule. Once daily. Full Spectrum Support.

Four Pillars of Full-Spectrum Support*

🧠 Mood + Mental Focus Calm Emotional Balance • Cognitive Flow State • Mental Sharpness*

⚡ Impulse Alignment Mindset Optimization • Neurochemical Harmony • Craving Control*

❤️ Eye + Heart Support Tissue Renewal • Blood Flow Support • Ocular Shield*

🌿 Cellular Vitality Energy + Vitality • Healthy Aging • Oxidative Protection*

Scan the QR Code: See Your Proof

Identity Verified: FTIR spectroscopy confirms genuine Crocus sativus L. saffron - not variants, not substitutes. Scientific proof of authenticity.

Purity Verified: All contaminants tested at undetectable levels. Exceeds safety standards by significant margins.

Safety Confirmed: Tested using USP pharmaceutical-grade protocols. Passes all microbiological and purity specifications with exceptional results.

Lab Accreditation: Tested by Ethos Analytics Laboratory, ISO/IEC 17025:2017 accredited, meeting international standards for accuracy.

Every batch is verified. Every bottle is scannable. Every quality claim is provable.

The Cleanest Formula Available

Just 3 Natural Ingredients: ✓ Saffron Extract (88.5mg) ✓ Rice Flour ✓ Vegetable Capsule (Hypromellose)

Absolutely Free From: Magnesium stearate • Microcrystalline cellulose • Artificial colors • Artificial flavors • Preservatives • GMOs • Gluten • Dairy • Soy

While competitors add questionable fillers, we keep it pure and simple. No hidden ingredients. No compromises.

Exceptional Value: 60-Day Supply

One bottle contains 60 capsules - a full 2-month supply at 1 capsule daily. Most others require 2 capsules daily for comparable potency. Saffron360's concentrated 88.5mg dose means more servings per bottle and more value for your investment.

Why Saffron Works

Used therapeutically for over 3,000 years, saffron is now backed by modern science. Research shows saffron's bioactive compounds support neurotransmitter systems including serotonin and dopamine, with clinical studies exploring benefits for mood, cognitive function, visual health, and metabolic wellness. We call this "Full-Spectrum Support" - because saffron may benefit multiple dimensions of wellness, not just one.

Premium Manufacturing Standards

🏭 NSF GMP Certified Facility - Pharmaceutical-grade quality control
🇺🇸 Made in Utah, USA - Supporting American jobs
✅ FDA Registered Facility - Compliant with federal regulations
🔬 Third-Party Laboratory Tested - Independent verification every batch
🌱 Vegan Capsules, Non-GMO - Clean, plant-based ingredients

Formulated by a Certified Wellness Professional

Developed under the guidance of a NASM Certified Nutrition Coach (CNC) and Certified Wellness Coach (CWC) committed to supplement transparency and evidence-based formulation. Founded on the principle that consumers deserve clean, verifiable supplements backed by science - not marketing hype.

Your Satisfaction, Guaranteed

We stand behind our commitment to transparency and quality with a 40 day from delivery return window. If you're not completely satisfied with your purchase, contact us for a full refund. Your trust matters more than a sale.

How to Use

Suggested Use: Take 1 capsule daily with food, or as directed by your healthcare professional.

Storage: Store in a cool, dry place. Keep out of reach of children.

Warning: Consult your physician before use if you are pregnant, nursing, taking medications, or have a medical condition. Do not exceed recommended dose. Not intended for use by persons under 18.

Experience the Saffron360™ Difference

In a market crowded with questionable quality and unverifiable claims, Saffron360™ stands alone: clinically-informed potency, absolute purity, complete transparency.

Scan the QR code. See the proof. Feel the difference.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Quantity

Recent clinical research has explored several key compounds that may have the potential to influence withdrawal symptoms by affecting neurotransmitter systems and stress response pathways. While the findings are promising, further research is needed to fully understand their effects. Here's what some of the latest studies reveal about specific ingredients you can find in Cannaleave's formulas:

1. GABA (Gamma-Aminobutyric Acid)

TLDR - Research shows GABA plays a crucial role in:

• Anxiety reduction during withdrawal*
• Sleep regulation*
• Stress response modulation*
• Natural calming effects on the nervous system*

Molecular Mechanism: GABA functions as the primary inhibitory neurotransmitter in the central nervous system. According to research published in Biomedicines (2024), GABA supplementation directly affects GABAergic signaling by binding to GABA-A and GABA-B receptors, leading to membrane hyperpolarization and reduced neuronal excitability, link.

Clinical Connection: The study demonstrated that oral GABA supplementation achieved significant central effects, contradicting earlier beliefs about blood-brain barrier penetration. During cannabis withdrawal, GABA supplementation helps restore balance to the dysregulated GABAergic system, link.

2. Vitamin B6 (Pyridoxine)

TLDR - B6 shows promise for issues encountered when quitting cannabis:

• Significant reduction in anxiety symptoms*
• Improved GABA synthesis*
• Enhanced stress management*
• Optimal dosing: 100mg daily*

A groundbreaking study published in Human Psychopharmacology (2022) by researchers at the University of Reading's School of Psychology and Clinical Language Sciences demonstrated that high-dose vitamin B6 supplementation significantly reduces anxiety symptoms. This mechanism is particularly relevant for cannabis withdrawal, where GABAergic system dysfunction contributes to anxiety and irritability, link.

Molecular Mechanism: Vitamin B6, serves as a critical cofactor in neurotransmitter synthesis, particularly in GABA production. Recent research published in the Journal of Psychopharmacology (2024) demonstrates that high-dose B6 supplementation increases inhibitory GABAergic neural influences while reducing glutamate concentrations, link.

3. L-Theanine

TLDR - L-theanine exhibits potential for managing several symptoms commonly associated with Cannabis Withdrawal Syndrome (CWS). This 2019 study, published in Pharmacological Research, concluded that L-theanine:

• Increases alpha brain wave activity*
• Enhances GABA production*
• Modulates glutamate and dopamine systems*
• Reduces cortisol levels*

L-theanine (200-400mg daily) demonstrates efficacy in managing key symptoms that overlap with cannabis withdrawal, particularly anxiety and sleep disturbances. Clinical research shows it promotes relaxation and improves sleep quality through GABA modulation and enhanced alpha brain wave activity, study link.

While direct studies on cannabis withdrawal are limited, L-theanine's well-documented anxiolytic properties make it a promising candidate for symptom management during withdrawal.

4. Passionflower

TLDR - Passion Flower shows promise for anxiety, insomnia and withdrawal symptoms, link.

• Eases withdrawal symptoms*
• Reduces anxiety and irritability*
• Helps reduce tolerance and dependance*
• Improves sleep quality without causing drowsiness*

Passionflower (Passiflora incarnata) shows particular promise for managing withdrawal symptoms through multiple mechanisms. This double-blind controled trial demonstrated its benzoflavone compounds may help reduce both physical and psychological withdrawal effects, link.

A key finding published in The Journal of pharmacy and pharmacology, exhibits Passionflower's benzoflavone molecule may help prevent the development of tolerance and dependence, while also potentially attenuating withdrawal symptoms through GABA receptor modulation, link.

Cannaleave; a 3-Phased Supplemental Approach

A hopeful horizon for natural CWS relief

Direct clinical studies examining the combined effects of Vitamin B6, GABA, L-theanine, and Passionflower for alleviating Cannabis Withdrawal Syndrome (CWS) have not yet been studied. Their individual mechanisms, however, suggest potential complementary benefits.*

Given their overlapping but distinct mechanisms targeting GABA pathways, sleep architecture, and anxiety - all key aspects of CWS - their combination could theoretically provide more comprehensive symptom relief than individual compounds alone.*

However, this hypothesis requires clinical validation through controlled studies before any definitive claims can be made.

While research continues on these powerful compounds, Cannaleave harnesses their synergistic potential through our strategic 3-phase approach. Each phase optimizes the timing of GABA, L-theanine, Vitamin B6, and Passionflower to target sleep, mood, and anxiety - the key challenges of cannabis cessation.*

Start with Phase-1: Cannaleave's Sleep+Recover, today and experience the difference.

*Regulatory Disclaimer: Before starting any new supplement regimen, individuals should consult with a healthcare professional. The content provided in this guide is for informational purposes only and is not intended to replace professional medical advice or treatment. Cannaleave supplements are not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration (FDA). Individual experiences may vary, and we encourage users to pay attention to their bodies and seek professional advice as needed.