Saffron360™
Saffron Supplement for Mood and Focus · Dopamine Support
88.5mg Pure Extract · Lab-Verified Quality
Scan the QR code on your bottle. See the lab results yourself.
In a 2023 ConsumerLab.com review, 2 of 6 saffron supplements tested did not contain their expected levels of key saffron compounds. Every bottle of Saffron360 links to its own batch-specific lab report from an independent laboratory, tested to ISO/IEC 17025:2017 standards.
You don't have to trust the label.
You can check it.
The Certificate of Analysis covers identity and purity. It does not measure mood or performance outcomes, those come from the published research below.
A concentrated, single-capsule dose
Saffron's studied dose depends on what was being measured. Mood trials cluster at 28 to 30mg a day. The satiety work ran at 176.5mg. Saffron360 sits at 88.5mg in one daily capsule, above the mood range and below the appetite one.
Where saffron acts
Dopamine and serotonin do different jobs. Dopamine drives wanting, the pull toward a thing before you have it, while serotonin runs closer to satisfaction and steadiness, the part that registers when enough is finally enough. A lot of what people call a bad week sits somewhere between those two.
Saffron carries three compounds studied against both systems: crocin, crocetin and safranal.
The largest trial so far ran 12 weeks. Lopresti and colleagues, writing in The Journal of Nutrition in May 2025, gave 202 adults 28mg of a standardized saffron extract every day and tracked mood, anxiety, stress and sleep quality against a placebo group. Sleep improved most in the people who started with the worst sleep.*
The extract in that trial was affron, a branded ingredient that Saffron360 does not use, and the dose was 28mg against our 88.5mg. Together those two facts make it ingredient-class evidence and not evidence about this product. We say so because the alternative is letting you assume otherwise.
Each heading below is an outcome saffron has been tested for in at least one human trial. Each one states the dose that trial used, the people it enrolled, and what it found. Where a trial found nothing, it says so.
Saffron's bioactive compounds have been studied for their influence on serotonin and dopamine signaling, and mood is by some distance the deepest and best-replicated part of that literature. It is also where the dose ranges are best established.*
Lopresti et al., May 2025, The Journal of Nutrition. 202 adults, 28mg daily, 12 weeks, against placebo.
One trial put healthy adults through a laboratory stress test and watched what happened to their heart rate variability. That is a physiological measure, not a questionnaire. The placebo group's fell. The saffron group's held.*
Jackson et al., February 2021, Frontiers in Nutrition. 56 healthy adults, 30mg daily, 8 weeks.
Two trials from the same research group tested saffron before bed, and sleep quality ratings improved in both of them. The second went further. It found that melatonin concentrations differed from placebo, a mechanism and not a feeling.*
Lopresti et al., 2020, Journal of Clinical Sleep Medicine, 63 adults, 14mg twice daily, 28 days. Follow-up 2021, 120 adults, a single evening dose.
8 weeks of saffron extract cut snacking by 55 percent. Placebo cut it by 28. The 60 women in that trial were not dieting, had not been asked to change anything else about how they ate, and were enrolled for being healthy and not for having a condition to treat.*
Gout et al., 2010, Nutrition Research. Satiereal, a branded extract, 176.5mg daily, roughly twice what one Saffron360 capsule carries.
Satiety and craving run on overlapping machinery, so a trial that measures snacking is measuring craving under another name. This is why saffron pairs with The Reset during a tolerance break. A t-break is mostly a craving problem wearing a schedule.*
Gout et al., 2010, Nutrition Research. See The Reset for the three-phase protocol.
Brain fatigue is not sleepiness. It is the state where things that used to register stop registering, where effort stops returning the feeling it once did, and where more sleep and more coffee both stop helping. Our quiz exists to name which version of it you have.*
Jackson et al., February 2021, Frontiers in Nutrition, on stress response. Take the Dopamine Renewal Quiz to find your pattern.
Saffron's effect on cognitive function has been reviewed across randomized trials. Most of that work enrolled older adults with existing difficulty and not healthy younger people, and the review says so plainly.*
Systematic review, 2020, Neurological Sciences, covering randomized controlled trials of saffron and cognitive function.
A 2020 meta-analysis pooled four randomized trials of saffron and cognition. Every one of them enrolled people with mild cognitive impairment or dementia, and the comparison was against donepezil, a prescription drug. That is the population this evidence describes, and it is not the general adult one.*
Ayati et al., 2020, BMC Complementary Medicine and Therapies. 4 randomized trials, all in mild cognitive impairment or dementia populations.
A 6-week trial gave 62 recreationally active adults 28mg of saffron extract daily and measured physical and mental performance. It found no significant difference from placebo. We report that because a page that only prints its wins is not worth reading.*
Randomized double-blind placebo-controlled trial, 2022. 62 recreationally active adults, 28mg daily, 6 weeks.
A double-blind trial ran two full menstrual cycles and compared saffron against placebo on a daily symptom diary. Saffron came out ahead.*
Agha-Hosseini et al., 2008, BJOG. Women aged 20 to 45 with PMS symptoms for six months or more, 15mg twice daily, two cycles.
Saffron's effect on cardiometabolic markers has been pooled across randomized trials, and the population in that work is adults carrying extra weight rather than the general public.*
Meta-analysis, Phytotherapy Research. Anthropometric and cardiometabolic indices in overweight and obese adults.
A 12-week trial at 100mg daily shifted the balance between pro-oxidants and antioxidants measured in blood serum, once at week six and again at week twelve.*
Randomized placebo-controlled trial. 75 participants with metabolic syndrome, 100mg daily, 12 weeks.
A four-week pilot in Norwich looked at gut bacteria alongside sleep in 52 older adults, on the idea that the two might move together. It is a pilot. Treat it as an early signal and nothing firmer.*
Gut-Sleep-Brain Axis pilot, 2025. Randomized and placebo-controlled, 52 adults aged 55 to 85, 30mg daily, 4 weeks.
Saffron is rich in carotenoids, though the ones it carries are crocin and crocetin and not the lutein and zeaxanthin that make up macular pigment. Every human saffron eye trial we found enrolled people with macular degeneration, so that research describes a clinical population and not a healthy one.*
Falsini et al., saffron 20mg daily in age-related macular degeneration. Named for scope, not as a claim about healthy eyes.
Fourteen headings is a lot for one plant, and the honest reason is not that saffron does fourteen separate things. Dopamine and serotonin reach into sleep, appetite, attention and mood, so a compound studied against those two systems keeps turning up wherever those systems happen to do their work. How much of the above follows from that, nobody has established.*
Three ingredients. Nothing else.
Developed under the guidance of JT Root, a NASM-certified nutrition coach with 30-plus years of personal wellness study, on the principle that supplements should be verifiable, not just marketed.
Your first 30 days are covered.
If Saffron360 isn't supporting you the way you hoped within your first 30 days, contact us for a refund. Register your bottle within that window and your coverage extends to 100 days from delivery.
Frequently asked questions
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before use, especially if pregnant, nursing, taking medications, or managing a medical condition. Not intended for use by persons under 18.
